[PDF] Study of relationship between a strain of E.coli and colorectal cancer | Semantic Scholar (2024)

The findings indicate that L. acidophilus and L. plantarum in people with a family history of CRC and patients with polyps may effectively prevent or reduce CRC progression.

Sensitive and specific molecular techniques might reveal the etiological role of bacterial infection in gallbladder carcinogenesis, and if bacteria are found to be causing cancers, eradication of such infections might help in reducing the incidence of some cancers.

AIEC strains are associated specifically with ileal mucosa in CD, and the abilities of E. coli strains to invade epithelial cells and to survive and replicate within macrophages were assessed using the gentamicin protection assay.

Broader appreciation of the existence and importance of ExPEC and better understandings of their distinctive virulence mechanisms, reservoirs, and transmission pathways may lead to effective preventive interventions against the morbid and costly infections ExPec cause.

High-throughput sequencing revealed that inflammation modifies gut microbial composition in colitis-susceptible interleukin-10–deficient (Il10−/−) mice, suggesting that in mice, colitis can promote tumorigenesis by altering microbial composition and inducing the expansion of microorganisms with genotoxic capabilities.

Various aspects of ExPEC are discussed, including its presence in food products, in animals used for food or as companion pets; the diseases ExPec can cause; and the virulence factors and virulence mechanisms that cause disease.

In Iran national cancer registry is based on laboratory registration with capability of 80 percent of case registry, and proper population based registry is started as a pilot project in some provinces which would be the corner stone of the comprehensive national cancer database.

The state of the art of the biology of cytolethal distending toxin and colibactin is summarized, focusing on the activation of the DNA damage response and repair pathways, and the cellular responses induced in intoxicated cells are discussed, as well as how prolonged intoxication may lead to chronic inflammation, the accumulation of genomic instability, and tumor progression in both in’vitro and in vivo models.

The detection of the colibactin genes associated with an ICE-like element in several enterobacteria provides new insights into the spread of this gene cluster and its putative mode of transfer.

Using metabolic function analyses of identified genes, the human genome is compared with the average content of previously sequenced microbial genomes and humans are superorganisms whose metabolism represents an amalgamation of microbial and human attributes.

Discovery of hybrid peptide-polyketide genotoxins in E. coli will change the view on pathogenesis and commensalism and open new biotechnological applications.

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